Oh boy...I once sprained my right ankle at 3:00 on a Saturday afternoon and had a gig that night. One of the guys in the band was staying at my house that weekend, and after lying down for a couple of hours with ice on my elevated ankle, he helped me load the drums in the car. The rest of the guys unloaded and carried the drums, I set them up and played the gig with the ankle wrapped in an Ace bandage. I was loaded full of Ibuprofen and in pain, but I made it somehow. When were done, everybody carried the drums out to the car. The playing wasn't too bad, but carrying was impossible.
I once played a gig pretty much one-handed when I had tendonitis in my left arm another time.